Manasi Bhavsar, Naman Mangukia, Archana Mankad
Tobacco
(Nicotiana tabacum) is considered as the tropical model plant for research
especially for alkaloid like nicotine. One of the public health problems
worldwide is harmful usage of tobacco that kills half of their consumers. On
the other hand, Nicotiana tabacum was used as chief medicinal plants by native
Americans, Amazonian and ancient Indians to cure poisonous reptiles’ bites and
multiple diseases. MicroRNA (miRNA) is a prime gene regulator amongst the class
of small-RNAs which binds with mRNA using translational repression or cleavage
mechanism. Till the date, tobacco plant derived miRNAs were studied to check
stress response in different biotic and abiotic condition and phylogenetic
analysis, plant growth and development. Thus, cross-kingdom approach helps to
understand the possible regulation as well as modulation in human health
targeted by tobacco specific miRNAs. Tobacco derived miRNAs along with their
targets were predicted and functionally annotated, pathway enrichment and
disease association were studied in this study. Conclusively, we can report
that N. tabacum miRNAs showed association with carcinoma and multiple
neural, cardiac disorders.
Nicotiana
tabacum (Tobacco), miRNA, Cross-kingdom, Human
health, Computational Genomics
VOL.13, ISSUE No.3, September 2021