Authors:

Akshi Valodara

Abstract:

Background and Aim

Prolong period of hyperglycemia in type 2 diabetes mellitus (T2DM) has been shown to increase the production of oxygen free radicals. T2DM complications such as diabetic retinopathy (DR) can be aggravated by hyperglycemia, which stimulates oxidative stress.

The purpose of the study is to find out the status of superoxide dismutase (SOD), glutathione (GSH), glutathione reductase (GR), and glutathione peroxidase (GPx) in healthy, T2DM and DR group.

Methods

This study includes 100 subjects of each category including healthy, T2Md and DR in western population of Gujarat.  The status of SOD, GR, GPx and GSH were determined in peripheral blood samples. In addition their statistical significance was also determined by ANOVA using Graph Pad Prism software and P value <0.05 were considering significant for this study. 

Results

Antioxidant enzymes like SOD, GPx and GSH level were significantly lower in T2DM and DR group (P value <0.05). While GR activity have been found high in T2DM and low in DR group (P value <0.05).  

Conclusion

Several microvascular complications of T2DM can be predicted by altering antioxidant enzymes status.

Keywords:

Oxidative stress, Antioxidant enzymes, Superoxide dismutase, Glutathione, Glutathione reductase, Glutathione peroxidase

Vol & Issue:

VOL.14, ISSUE No.1, March 2022